His trip comes days after the announcement of Egypt-brokered ceasefire between Israel and Palestinian factions in Gaza Strip. "And that begins with tackling the grave humanitarian situation in Gaza and starting to rebuild", he said.
He said the USA would work to rally global support around that effort and make its own "significant contributions", which would be announced later in the day.
Biden announced the visit, saying Blinken would work with regional partners on a "coordinated global effort to ensure immediate assistance reaches Gaza". Blinken will not be meeting with Hamas, which does not recognize Israel's right to exist and which Israel and the US consider a terrorist organisation. After the meeting with Netanyahu, the top USA diplomat is expected to tour Ramallah, Cairo and Amman. The Biden administration had initially hoped to avoid being drawn into the intractable conflict and focus on other foreign policy priorities before the violence broke out.
He will begin his visit in Israel, where Prime Minister Benjamin Netanyahu is fighting for his political life after a fourth inconclusive election in two years.
"If Hamas breaks the calm and attacks Israel, our response will be very powerful", the Israeli premier said, following his talks with the USA top diplomat.More news: United States agencies examine reports of early COVID-19 infections in Wuhan lab
Palestinian President Abbas praised an initiative announced by President Abdel Fattah al Sisi to rebuild the Gaza Strip following the recent Israeli onslaught.
During the last major hostilities between Israel and Hamas, a 2014 war that lasted seven weeks, Israel's central bank estimated the country's economy took a 3.5 billion shekel hit, plus almost the same amount in damage to the tourism sector.
At least 284 Palestinians were killed in Palestinian territories by the occupying forces since April against the backdrop of an Israeli court verdict to evict Palestinian families from their homes in the Sheikh Jarrah neighbourhood in occupied East Jerusalem.
Tension in the region is still high. The evictions were put on hold just before the Gaza fighting erupted, but the legal process is set to resume in the coming weeks.
Israeli police said an attacker stabbed two young Israeli men in Jerusalem on Monday before police shot him dead. The Israeli army referred questions to the Border Police, which did not respond to requests for comment. He also plans to meet with Palestinian Authority President Mahmoud Abbas.
Abbas, who canceled the Palestinian elections for the first time in 15 years last month, saw the collapse of the Fatah movement suffering an embarrassing defeat, but many Palestinians believe it has lost all legitimacy. A crowd of worshippers at Al-Aqsa chanted against the Palestinian Authority and in support of Hamas on Friday.More news: Local Pharmacist Ready to Complete AstraZeneca Vaccinations More
But Abbas is still seen internationally as the representative of the Palestinian people and a key partner in the long-defunct peace process.
Blinken will also visit neighboring Egypt and Jordan, which made peace with Israel decades ago and have acted as mediators in the conflict.
The Biden administration is facing pressure from within the Democratic party to recalibrate its stance on Israel.
The association, which represents some 1,500 firms and 400,000 workers, said the loss was mostly due to employees choosing to stay at home due to the almost nonstop rocket fire from Gaza.
He said it was not the right time to resume negotiations immediately, but that measures could be taken to destroy hundreds of homes in Gaza and fix the damage caused by Israeli airstrikes that damaged infrastructure.More news: COVID-19: downward trends continue as Alberta starts May long weekend