More than 200 firefighters and emergency personnel supported by four helicopters and a spotter aircraft battled the blaze as it continued to burn late Sunday.
This comes after at least two floors at the Jagger Library were destroyed. The fire was at 6pm burning on campus grounds and had damaged the Special Collections Library.
Runaway flames set several University of Cape Town buildings ablaze as firefighters used three helicopters to water-bomb the area.
Wildfires are common in the national park lands that make up the heart of Cape Town, with high temperatures and stiff winds Sunday contributing to the rapid spread of the fire.
One firefighter was injured and being treated at a hospital, according to the Cape Town fire and rescue department.
Wildfire wey don go "out of control" dey burn for Table Mountain for Cape Town, South Africa.
Fire-fighting teams teams from Working on Fire and Table Mountain National Park were deployed to fight the blaze.
A first alert went up shortly before 9 am (0700 GMT), the city said.More news: Alex Ferguson has given his reaction to the new European Super League
Reports say Fuller House - a student residence - is on fire - but all students were evacuated.
University of Cape Town na one of di best universities for Africa.
Other campus buildings also caught fire, and a historic windmill nearby burned.
"At this stage, there's no cause to evacuate, but we ask that residents adhere to the following: close all windows to prevent drafts and reduce heat, damp down your garden using a hose or irrigation system", Powell said.More news: Latest updates: Philip's coffin in Inner Hall ahead of funeral
In another video, tweeted by the local government, flames are seen raging inside an old building lined with columns as smoke plumes rose from its roof.
Residents in the area have been warned of smoke and soot in the air, and told to keep windows and doors closed.More news: Japan Prime Minister Biden's First Guest With Push On 5G, Climate, China