A full of 2,397 folks have misplaced their lives in the course of the pandemic.
As of 2pm yesterday, 1,582 COVID-19 patients are hospitalised, of which 146 are in ICU.
"What we can do today, out of respect for those who have lost their lives and those now in hospital or ICU - and those caring for them - is to hold firm and stay home".
The new United Kingdom variant of the disease, and ten of thousands of Irish people returning home from overseas for Christmas, are also highly likely to have contributed to the explosion in cases.
Dr Ronan Glynn, deputy chief medical officer, said at least one in three patients admitted to hospital or critical care this month have been under the age of 65.More news: B.C. records 446 new cases of COVID-19, 9 deaths Tuesday
As of 6.30pm on Monday, just 30 ICU beds across the country remain available, while 143 patients are receiving treatment for COVID-19 in ICUs.
Overall, more than 1,700 people are now receiving treatment for COVID-19 in Irish hospitals.
The health chiefs said the surge in expected hospital admissions can not be solved by creating more beds because the staff are not there to care for increased numbers of patients.
The selection of individuals in healthcare facility with coronavirus is continuing to rise, with 1,700 folks now battling the virus across the nation.
Paul Reid, chief executive of the HSE, repeated his call for people to stay at home.More news: Photos of free school meal packages in the United Kingdom spark outrage online
When Ireland came out of a strict six-week lockdown in December it had one of the lowest levels of COVID-19 cases in Europe. "Every time we wash our hands, wear a face covering and keep a two metre distance from others, we are protecting the most vulnerable in our society and our frontline healthcare workers and giving all of us much needed additional time for more vaccines to be administered".
There has now been a total of 2,397 Covid-related deaths in Ireland, while 155,591 people have tested positive.
Ireland had the fastest-growing incidence rate in the European Union last week, fueled by the relaxation of restrictions ahead of Christmas and the increasing prevalence of a new, more transmissible COVID-19 variant first discovered in England.
Today's update comes after the EU Commission confirmed that AstraZeneca has finally applied for EU approval of their COVID-19 vaccine.
He tweeted: "If approved this vaccine will allow significant scaling up of vaccination programme".More news: Dana White's proposal to McGregor to focus on UFC