The Uruguayans, of course, will try to play as strictly as possible on the defensive in the match with the Brazilians.
The rest? Well, that's where the surprises live.
Salomon Rondon headed home a late victor against Chile to get Venezuela their first points on the board.
Here we present the records that were scripted in matchday four.More news: Jesy Nelson Announces Extended Time Off From Little Mix
After leaking goals in their first couple of matches, Uruguay finally emerged with their first cleansheet of the qualifiers the last time they stepped onto the pitch.
That's something to note when Everton and Man United meet in a League Cup quarterfinal on December 23.
Victory in Montevideo left Brazil on top of South America's qualifying standings on 12 points with four wins from four games. The bad news is two of its three draws came at home to Peru and Bolivia, the two teams stuck on one point so far.
"The story of today's game was different from the one against Venezuela (a 1-0 win at the weekend)".
Marcelo Moreno answered in the 41st minute for Bolivia and the visitors made it 2-1 just before the break on a Boris Cespedes goal.More news: Man Utd handed boost as Telles tests negative for coronavirus
A still of Richarlison celebrating after he scored the second goal for his team.
Red card follows golazo.
Taking time to find their feet in the qualifiers, Uruguay's 3-0 routing of Colombia the last time around was the first statement of intent from the side.
Nicolas Gonzalez and Lautaro Martinez scored 11 first-half minutes apart as Argentina stayed unbeaten in qualifying.
Brazil continued their flawless start to the qualifiers for the 2022 World Cup with a 2-0 win over Uruguay while rivals Argentina stayed in touch with an easy win in Peru.
Good, good stuff from Lo Celso here.More news: FAA Clears Boeing 737 Max to Fly Again
The Club Leon man was set up by Xavier Arriega to make it 2-0, then cued up Michael Estrada and Gonzalo Plata for goals before the latter was sent off in the 80th minute.