Its first crewed flight took place in May, when Doug Hurley and Bob Behnken launched on a jaunt to the station.
NASA has described the precise launch time as an "instantaneous launch window", meaning the mission must leave on the dot if it wants to catch the station as it circles the Earth.
The launch has already been delayed twice for testing and weather. But the launch was postponed for a day due to forecasts of gusty winds - remnants of Tropical Storm Eta - that would have made a return landing for the Falcon 9's reusable booster stage hard, NASA officials said.More news: Violent clashes in DC after Trump backers' election protest
NASA astronauts, from left, Shannon Walker, Victor Glover, and Michael Hopkins and Japan Aerospace Exploration Agency astronaut Soichi Noguchi leave the Operations and Checkout Building on their way to launch pad 39A for the SpaceX Crew-1 mission to the International Space Station at the Kennedy Space Center in Cape Canaveral, Fla., Sunday, Nov. 15, 2020. The Dragon capsule on top - named Resilience by its crew in light of this year's many challenges, most notably COVID-19 - reached orbit nine minutes later.
The event will feature commentary from former astronauts Peggy Whitson, Mike Massimino, and Garrett Reisman, with Mike Hopkins, Victor Glover, Shannon Walker, and Soichi Noguchi participating in the launch. Had SpaceX been able to launch on the 14th, the cruise phase would have been just 8.5 hours long - perhaps the fastest crewed USA space station rendezvous ever. "And now it's time for us to do our part".
Musk - who disclosed on the eve of the launch that he "most likely" has a moderate case of coronavirus, despite mixed results - was replaced in his official duties at Kennedy by SpaceX President Gwynne Shotwell. SpaceX would launch yet another crew in late summer or early fall.More news: Biden's Chief Of Staff Says McConnell Still Hasn't Spoken To President-elect
Mission preparations were under way Sunday afternoon as NASA officials pegged launch probability at 50%, maintaining plans to launch but monitoring wind and cloud formation near the rocket pad that could postpone the mission to Wednesday. Similar pleas for SpaceX's first crew launch on May 30 went unheeded.
NASA is expected to commission the spacecraft to regularly shuttle astronauts to and from the space station. The space agency will save millions by no longer needing to buy seats on Russian Soyuz capsules.
Falcon 9 B1061 successfully lifts off with four astronauts on Crew Dragon's operational launch debut. The company is still working to overcome software problems following last December's marred space debut of its Starliner capsule.More news: MI governor seeks shutdown of Great Lakes oil pipeline