De Villa said at a press conference on Tuesday that only children under two years old and people with a medical condition that prevents them from wearing masks can be exempted from the bylaw.
"I can not emphasize enough how important it is for all of us to remember that we are still in the middle of a pandemic", De Villa said during a news conference Tuesday.
Toronto city council approved a bylaw Tuesday that makes face coverings mandatory in indoor publicly-accessible spaces.
Fines for violations have not yet been set by local courts, though the city solicitor said she expects the figure to be "in the ballpark" of $750 to $1,000.
Though the bylaw means nearly everyone must wear a face mask, Tory said there will not be aggressive enforcement as the city does not have enough resources to do so.
Many were wearing masks headed inside from the parking lot, and most said making them mandatory could only help.More news: Hundreds of elephant carcasses discovered in Botswana over the last two months
In the United States, cities in the Sun Belt region are seeing record surges of COVID-19 cases, which experts attribute to states implementing economic reopening plans too soon.
"It is about respecting and protecting each other", said Tory during a news conference Tuesday morning before city council's meeting.
Tory said earlier in the day that the temporary bylaw would not affect social gatherings, but will apply to public spaces including stores and other businesses.
On Monday night, a spokesperson for Health Minister Christine Elliott told media outlets that an Ontario-wide law isn't necessary and public health units have the power to enact mandatory face covering policies locally.
The report recommends all city residents to wear a face covering when in public spaces and businesses.More news: Launch of NASA Mars rover delayed again, 2 weeks left to fly
The city appears to be putting the onus for compliance on store and business operators and insists that education - and not enforcement - will be key to the success of the mask initiative.
The mayor said he understands how wearing a mask gets uncomfortable sometimes but doing so can reduce their risk of being infected with the coronavirus. "It is apples and oranges".
The Canadian Constitution Foundation, a right-leaning think tank, has been critical of mandatory mask orders in other Ontario municipalities, calling them an affront to civil liberties.
Masks have already been made mandatory on the TTC starting July 2.
He was joined by Tory, Mississauga Mayor Bonnie Crombie, Brampton Mayor Patrick Brown, Markham Mayor Frank Scarpitti and Vaughan Mayor Maurizio Bevilacqua in a request to make face coverings mandatory indoors, provincially.More news: Bubba Wallace: Nascar president said it was right to fear hate crime