Some 44,000 people had now signed a petition calling on Ms Krewson to resign after she "endangered the lives of protesters by releasing their names and addresses".
Nearly 100,000 people have since viewed the same video, which comes after Mr Trump retweeted a video in which someone yells "white power" at protesters in a Florida.
The video was ABC News' clip of a man pointing a large rifle at the line of protesters while his female partner swings a tiny pistol next to him.More news: It’s all over now, Rolling Stones tell USA president
The video of the couple outside of their homes is also causing the word "AR-15" to trend on Twitter.
The protesters are shown standing on the sidewalk and the street.
Some called for the husband and wife to be charged for holding guns while on their property.More news: Boeing can begin test flights of the 737 Max, FAA says
Many critics described the couple as "Ken and Karen", playing on the viral "Karen" nickname for white women who bring their trivial complaints to authority figures. Its exterior is made from limestone and marble, and its interior has been decorated to look like various Renaissance palaces from Europe, according to the profile. The city's politician is facing calls for her resignation after she doxxed people who wanted to defund the police department.
The group of protesters apparently crashed the gate into the neighborhood, as the incident took place on a private street, Portland Place, according to the St. Louis Post-Dispatch.
The protestors were on their way to Mayor Lyda Krewson's house.
"As a leader, you don't do stuff like that ... it's only right that we visit her at her home", said state representative Rasheen Aldridge, speaking into a megaphone at the protest on Sunday.More news: UK could lockdown city of Leicester over virus fears