Home Secretary Priti Patel said the rules will take effect June 8 and will apply to arrivals from all countries except Ireland, which has a longstanding free-movement agreement with the U.K. Ireland is expected to announce similar measures for people arriving there.
However, Professor John Edmunds - a member of the advisory group SAGE - poured cold water on those plans.
He told Nick Ferrari: "Quarantining people coming into the country really matters when of if we get our incidence really low - so if our incidence is much lower than other countries then it makes some sense to do that".
Under the new plans, passengers will have to fill in a form providing their contact and travel information to enable them to be traced if infections arise.
Britain is now piloting a contact tracing smartphone app to better identify cases and the spread of the virus nationally.More news: McConnell: Dems Trying to ‘Incentivize’ Unemployment in Latest Coronavirus Relief Bill
The home secretary said the new measures aim to "keep the transmission rate down and prevent a devastating second wave".
As the number of infections within the United Kingdom drops, we must now manage the risk of transmissions being reintroduced from elsewhere. Materials will be available in English and 9 other languages.
If their planned accommodation does not satisfy the authorities, arrivals will be put up in facilities arranged by the government, the Home Office says.
People should use personal transport, such as a auto, to travel to their accommodation where possible. Once they arrive there, they should not leave their accommodation for 14 days.
Officials would not answer on whether the measure will be in place long-term. But they should avoid contact with anyone they are staying with and minimise time spent in shared areas and use separate bathrooms if possible. They should not have visitors, including friends and family, unless they are providing essential support.More news: Experimental COVID-19 vaccine shown to be effective in monkeys
Visitors will not be allowed, unless they are delivering food and other essential items or providing essential services.
In another development, China's COVID-19 vaccine trial has shown some promising results as world is seeking solutions to the pandemic.
Once self-isolation is complete people should follow the current government guidelines on social distancing measures.
The new rules will apply to all global arrivals except Ireland from June 8 and come after weeks of calls for tougher restrictions to curb the spread of COVID-19.
Stephen Hale, chief executive at Refugee Action, said: "The UK has a legal obligation and a moral responsibility to protect people fleeing war and persecution".More news: Tiger Woods: What's in the bag for coronavirus relief match
"When it comes to air bridges. we should be absolutely open to all ideas, this is not for today but this doesn't mean we should rule this out in the future", she said.