City were relentless with Aguero - who now has 249 goals for the club in all competitions - wrapping up his treble in the second half to set a new Premier League record of 12 hat-tricks, passing Alan Shearer's mark.
When English players are included, Aguero is fifth in the all-time Premier League standings.
'I think it's nice for him.More news: Gigi Hadid And Zayn Malik Back Together?
Villa boss Dean Smith moved for Reina after the struggling Premier League club's first-choice keeper Tom Heaton was ruled out for the rest of the campaign.
Manchester City have won four of their last five games in the Premier League this season to leave them in third place in the table as things stand.
The Argentina worldwide beat Henry's tally on Sunday at Villa Park as he scored City's third and fifth goals in their 6-1 win.
Meanwhile, Guardiola insists Sergio Aguero will "die scoring goals" after his record-breaking hat-trick demolished Villa.More news: Lori Harvey Charged For October Hit & Run Incident
De Bruyne was coached by Henry at Belgium and, while he was delighted for Aguero, he said they will both be remembered as extraordinary players. "To come and do this on a consistent basis for nine or 10 years is unbelievable".
"They are the favourites but I am happy to see someone upsetting the big teams, even though I used to play for the big teams, I want to see someone really test City and make things hard for them, but I think they will have too much for Villa on this occasion".
"It's not always necessary to compare people, just be happy and maybe be grateful that these guys play there".More news: Trump welcomes court decision on US-Mexico border wall