South Africa are short on destructive flair in their batting line-up, placing much reliance on wicketkeeper Quinton de Kock to take the fight to the English bowlers.
The series is squared at 1-1 heading into the third Test at St George's Park on Thursday.
Five of those losses were in Sri Lanka and India, on each occasion after Du Plessis lost the toss in countries where the toss is usually more important than in South Africa.More news: Duchess Meghan Markle returning to Vancouver Island
The England captain is contending with an upset stomach just four days out from the Port Elizabeth contest.
The four-match series is locked 1-1 after England's 189-run win in Cape Town.
Where can I get tickets for South Africa vs England? .
Dom Bess, not part of the original touring group, did an adequate job for England, bowling economically but picking up only one wicket in each innings.More news: Boeing 737 Max messages raise safety questions
Meanwhile, Mark Wood said that both Jofra Archer and Chris Woakes are ahead of him when it comes to team selection for the upcoming third Test against South Africa. He can be back assertion for a spot into the beginning line-up.
The Somerset spinner, who has been unable to recover from sepsis since the New Zealand tour, joins James Anderson and Rory Burns home as the tourist nightmare continues with injuries and illnesses.
With the ground capacity reduced because of building work, local followers found most of the tickets had been snapped up by tour operators, with Cape Town being a particularly attractive destination for England's travelling supporters.
The St George's Park metal musical organization, using their power to get neighborhood followers performing and swaying into the old primary stand, provides a uniquely South African taste into the Test match.More news: Pope Benedict XVI makes rare statement on priest celibacy debate