The Falcon 9 rocket and Dragon space capsule rumbled aloft at about 2:48 a.m. local time from Cape Canaveral Air Force Station in Florida.
SpaceX couldn't resist the Star Wars Day connection - Saturday is May 4.
The Crew Dragon capsule that was destroyed is the same capsule that was utilized during the SpaceX's Demo-1, the non-crew test flight in March where it was able to successfully dock with the ISS before making its journey back to Earth without any issue. Both problems were quickly resolved with equipment replacements: a power-switching unit in orbit and a generator at sea.
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The booster likely will be reused for SpaceX's next station supply run.
The launch was a week after SpaceX's Crew Dragon capsule, a different model meant to carry people, exploded in a test firing.
The California-based company is also under contract with NASA, along with Boeing, to transport astronauts to the space station.More news: China says trade envoys preparing to go to Washington
SpaceX has confirmed that the Crew Dragon capsule underwent an explosion during a recent test.
Koenigsmann also said in his statement, 'While it is too early to confirm any cause, whether probable or crude, the initial data indicates that the anomaly occurred during the activation of the SuperDraco system.
SpaceX has been restocking the space station since 2012. Much of the focus this year is on the first flight with humans on board.
Astronauts have not launched from Cape Canaveral since the last space shuttle mission in 2011, instead riding Russian rockets at a steep cost to NASA. The AP is exclusively responsible for all content.More news: May looking at second Brexit vote options if talks fail