The gory discovery - published on Thursday in "The New England Journal of Medicine' - is a rarity in archaeology, and researchers called the find from the ruins of Herculaneum near Pompeii "sensational".
Most of his neighbors in the ancient seaside town of Herculaneum, about 11 miles north of Pompeii, had succumbed to the volcano's eruption on the beach.
The new report offers further (and rather horrifying) insight into how Vesuvius' victims died-a subject that continues to confound experts.
"This is the first ever discovery of ancient human brain remains vitrified by heat".More news: Troops Suffered Traumatic Brain Injuries In Iranian Missile Attack
Herculaneum, named after the Greek god Hercules, was a popular resort town for the rich northwest of Pompeii when Vesuvius erupted. He is believed to have been the custodian, or caretaker, of a place of worship - the Collegium Augustalium at Herculaneum.
As they analysed the charred wood found near the corpse, the scientists suggested the temperature in the room at the time of the eruption had reached a maximum temperature of 968 degrees Fahrenheit (520 degrees Celsius).
His skeleton was charred and cracked into many pieces, and decades would go by until researchers found anything more.
"I saw something shining inside the head", he said, "and it was these small, glassy black fragments that were just attached inside the skull".
"This material was preserved exclusively in the victim's skull, thus it had to be the vitrified remains of the brain". Petrone immediately suspected the material was brain tissue that had undergone vitrification, a process that occurs when tissue is burned at a high heat and transformed into a glass or glaze.More news: NASA wants your help to name their newest Mars rover
Petrone said the finding confirms his theory about how the extreme heat coming from Vesuvius killed people.
"All of this evidence was undeniable evidence that it was the Guardian's brain that was glazed by the high temperature of the ash wave that killed him", said Petrone. This research, in fact, contradicts a 2018 study headed by Patrone, which found that a pyroclastic surge made victims' blood boil and their skulls explode.
Although the remains were found in the 1960s, the glass-like remnants? of the person's brain were recently uncovered in the skull.
The fatty acids and proteins found in the substance, and the localised nature of the material, suggest this is a brain exposed to sudden, intense heat, according to the researchers. The extreme temperature would have been hot enough to "vaporize soft tissues" in the victim's body and burn every last trace of fat.
Study co-author Piero Pucci of the Centro di Ingegneria Genetica-Biotecnologie Avanzate in Naples found that the proteins within the material matched those known to be found in different areas of the human brain.More news: LaLiga: Barcelona players banned from tackling Messi in training