U.S. President Donald Trump hit back later on Twitter, writing that Khamenei should be careful what he says.
Zarif said Iran expects India to play a positive role in the region has it has a large stake there.
Regarding the accident of the Ukrainian airplane, Khamenei explained it as "a bitter accident" that "burned through our heart".
He included: "Our adversaries were as pleased regarding the airplane accident as we were unfortunate ... pleased that they located something to inquiry the [Islamic Revolutionary] Guards, the militaries, the system".
Iranian Foreign Minister Mohammad Javad Zarif said on January 17 that he had met his Canadian counterpart, Francois-Philippe Champagne, in Oman to discuss cooperation among nations affected by the disaster - along with Canada, Iran, Ukraine, Afghanistan, Sweden, Britain, and Germany had passengers aboard the doomed flight.More news: Ducks work overtime to hit hurricanes on Sam Steel
The Revolutionary Guards can take their fight beyond Iran's borders, the supreme leader said on Friday, responding to the United States killing of his country's most prominent commander and to anti-government unrest at home over the downing of an airliner.
"Their economy is crashing, and their people are suffering".
"The noble people of Iran-who love America-deserve a government that's more interested in helping them achieve their dreams than killing them for demanding respect".
Trump went on to tweet a message to the Iranian people while including a riff on his 2016 campaign slogan, "Make America Great Again".
Trump responded with a tweet on Friday evening, adding the zinger that Khamenei had "not been so Supreme lately".More news: Trump Welcomes LSU Tigers to White House
Why is leading Friday prayers significant? Khamenei had also warned against any U.S. strikes on Iran over its nuclear program, saying the United States would be destroyed "10 times over".
The Ukraine International Airlines (UIA) Boeing 737-800 had just taken off from Tehran en route to Kyiv on January 8 when it crashed, killing all 176 people on board.
The plane was downed shortly after it took off from Tehran's main worldwide airport, killing all 176 people on board, mostly Iranians and Canadians. After Tehran announced its responsibility in the crash, angry protesters took to the streets, with security forces firing tear gas and live ammunition at demonstrators.
This article was first published on DW.More news: Marvel's Iron Man VR has been delayed