The cave-in happened at around 5:30 p.m. on Monday (4:30 a.m. ET) at a bus stop located outside of a hospital.
Footage captured at the scene shows people running from the collapsing road.
Subsequent footage shows rescuers perched precariously between the edge of the sinkhole and a nearby bus stop, as they pull someone from the hole.
The hole reached nearly 10 meters (around 33 feet) in diameter and a rescue effort involving nearly 1,000 emergency responders and 30 vehicles is underway at the site, state media reported.More news: This is what Samsung's Galaxy S20+ 5G looks like
While somewhat uncommon, sinkholes crop up from time to time in China, with one big 60-meter hole opening up in Guyuan city last September to devour a taxi cab whole.
The incident has also left 16 people injured, but they are in stable condition now.
The sinkhole was 80 square metres (860 sq ft) in area and an investigation into its cause was under way.
It's unclear how many passengers were on the bus, and the deceased have not yet been identified.More news: Catch me if you can says Ormsby at Hong Kong Open
In December, three people fell into a giant sinkhole in Guangzhou City when the road suddenly collapsed near a construction site.
Though the cause of the accident was yet to be ascertained, an investigation into the incident is underway.
In 2018, a sinkhole opened up on a busy sidewalk in the city of Dazhou in southwestern China, killing four people, the BBC reported.
In 2015, five people died after being swallowed by a 32-foot sinkhole in the industrial city of Shenzen just outside Hong Kong.More news: Using Huawei in United Kingdom 5G network 'would be madness', USA claims