LSU, meanwhile, defeated Georgia 37-10 to clinch the SEC Championship Game, as Joe Burrow strengthened his MVP credentials.
The undefeated Big Ten champion Ohio State Buckeyes are underdogs heading into the College Football Playoff. Playing in the Big Ten, Ohio State faced hard games almost every week, playing five teams that ended up in the final rankings.
Plus, Ohio State's pass rushing attack is downright absurd.
Ohio State earned a 34-21 win over No. 8 Wisconsin on Saturday night after erasing a 21-7 halftime deficit with 27 unanswered points in the second half. Georgia's loss to LSU and No. 5 Utah's defeat to No. 13 OR in the Pac-12 title game means both programs are 11-2, while No. 6 Oklahoma improved to 12-1 after beating No. 7 Baylor in the Big 12 Championship Game.
It will also be the Buckeyes' fourth bowl game versus Clemson, with the most recent coming in the 2016 College Football Playoff, also in the Fiesta Bowl.More news: Houston officer dies following shooting in city's East End
Teams from the same conference can't be paired in the first round unless they didn't meet in the regular season.
"I think it helps a lot that we've played in a lot of big games", said center Josh Myers, who remembered watching OSU's 2016 CFP semifinal against Clemson from a hotel room as a high school senior.
When does the College Football Playoff start?
The Buckeyes and the Tigers will kick off at 8 p.m. E.T. on ESPN.
No. 3 Clemson opened as a 2-point favorite over No. 2 Ohio State on Sunday at Caesars Sportsbook.More news: Georgia injuries pile up, Blaylock, Grant out in title game
What a wildly disrespectful line for Oklahoma and fans of the Sooners. The national championship game is set for January 13 in New Orleans. The Tigers and Buckeyes will face off December 28 in the Fiesta Bowl in the second semifinal.
Oddsmakers think LSU is going to crush Oklahoma in the college football playoff.
When are the other New Year's Six Bowl scheduled for?
The Buckeyes own a 24-25 all-time bowl record with wins in each of the last two years in the Goodyear Cotton Bowl and the Rose Bowl Game presented by Northwestern Mutual. Central in Mercedes-Benz Stadium in Atlanta.More news: Walmart Apologizes For Christmas Sweater With Apparent Drug Reference