Andy Murray lost his first singles match in months, falling in straight sets to Richard Gasquet in the first round of the Western & Southern Open in Cincinnati on Monday.
The 45 time ATP tour victor, had been offered a wildcard by the United States Tennis Association, but the three-time Grand Slam victor said: "We were hoping to hold a wildcard until nearer the time and see how it feels".
Andy Murray is now considering playing singles at Winston-Salem next week and he will play doubles in NY.
Andy Murray will not take up a wildcard invitation for the US Open Men's singles after losing his first singles match since the Australian Open.More news: Aaron Mooy signs for Brighton on year-long loan from Huddersfield
"It was more likely that I was not going to [play] because although I did fine in the match today, physically my legs felt quite heavy at the end of the match, and that's probably not going to change a whole lot in a couple of weeks".
"But I feel a bit disappointed, I feel like I can do better and there are a lot of things I can work and I will go away and I will go away and do that and be hopefully better next time".
"When he drop-shotted, there was a few times I didn't even run to the ball, didn't react to it, and that's nothing to do with my hip".
"But the US Open were announcing their wildcards today and I didn't feel I was able to make that decision before today's match".
The 32-year-old confirmed that he still has some ways to go before returning to his top fitness and will limit his singles activity as he continues to recover from hip resurfacing surgery in January.More news: 'Little Women' Trailer: Greta Gerwig's Star-Packed Adaptation Of Classic Novel
'The way to get that back is by playing matches. Though the talented Murray brothers started off very well as they defeated the strong duo of Nicolas Mahut and Edouard Roger-Vasselin with the close margin of 6-4, 6-7 (7), 10-5.
"I'm not going to play the U.S. Open singles".
Next up for Kyrgios is a first career meeting with eighth seed Karen Khachanov in the second round on Wednesday.
World number two Rafa Nadal, the second seed, withdrew overnight, citing fatigue after winning his fifth Rogers Cup title on Sunday.
In the women's draw at the ATP-WTA event, Venus Williams reached the second round with a 7-5, 6-2 victory over American compatriot Lauren Davis.More news: Facebook app for Android to have Dark Theme soon
Marin Cilic, the men's 14th seed, was beaten by 39th-ranked Radu Albot 6-4, 7-6 (6).