Colbert quickly followed up by asking Reeves what he thinks happens when we die.
Halle Berry joined Keanu Reeves in the cast of John Wick 3: Parabellum and the movie looks promising. The pair were discussing the eagerly awaited return of stoner-bro duo Bill and Ted who are tasked with writing a song in 80 minutes to save the world in their upcoming film Bill and Ted Face the Music.
After pausing for a few seconds, Keanu said: "I know that the ones who love us will miss us".
His daughter with ex-girlfriend Jennifer Syme was stillborn in 1999.More news: AEW Coming To TNT
"The grief proved too much for their relationship, which ended several weeks later".
Keanu was struck by these heartbreaking losses just years after his close friend and fellow actor River Phoenix died in 1993. According to People, the actor lost his best friend to a drug overdose in 1993 and his girlfriend Jennifer Syme died in a vehicle crash in 2001.
A source told People magazine Keanu was "finding it very, very hard to cope with her death". To which Colbert said, "You're facing your own mortality and the mortality of all existence, wow".
Colbert's father James and two closest brothers Peter and Paul died in a plane crash.More news: Britney Spears Not Ready for Vegas Residency, Says her Manager
The Beirut-born Canadian's profound response earned him a firm handshake from the 56-year-old ordained minister and an audible "Awwww" from the previously chuckling audience.
Keanu was on the talk show promoting his titular, super-assassin role in John Wick: Chapter 3 - Parabellum, which hits United Kingdom theaters this Wednesday and U.S. theaters this Friday.
John Wick: Chapter 3 Parabellum hits theatres this Thursday, May 16th. So while others stick around the theater to watch the credits and see if there will be a John Wick: Chapter 4 - Paralellagram, you're going to be able to immediately make a beeline for the exit.More news: Rick and Morty Season 4 Gets Premiere Date on Adult Swim