City officials announced a public health emergency over the outbreak following the diagnoses of 285 cases of measles since October.
The order concerns all people living or working in four zip codes of Williamsburg, northwest Brooklyn, where some residents oppose vaccines on religious grounds - although neither Jewish texts nor local Jewish authorities advise against vaccination.
"When you make the decision not to vaccinate your child, please understand you're also making that decision for the people around your child", Ms Palacio said. None proved fatal, but 21 patients required hospitalization and five were admitted to intensive care. Israel, for instance, also has a current measles outbreak.
It says the vaccine is 97 percent effective.
"There's no question that vaccines are safe, effective and life-saving". "The faster everyone heeds the order, the faster we can lift it". Anyone who resists could be fined up to $1,000.More news: Adani inches closer to constructing Carmichael coal mine after Aussie nod
News of the order got a mixed reaction among Orthodox Jews in Williamsburg, the Brooklyn neighborhood affected by the order.
Now any school out of compliance will immediately be issued a violation and could be subject to closure, the Mayor's office said.
As The Washington Post's Frances Stead Sellers reported, government pushes for inoculations and the barring of unvaccinated children from public spaces have prompted a backlash among anti-vaccination activists, whose misinformation campaigns have led to declines in immunizations against one of the world's most contagious diseases.
New York City on Tuesday, April 9, declared a public health emergency and ordered mandatory measles vaccinations amid an outbreak, becoming the latest national flashpoint over refusals to inoculate against risky diseases.More news: Real Madrid table bid for Chelsea star Eden Hazard
"I would expect that this outbreak is going to get bigger before it comes under control", said Dr. Amesh Adalja, a senior scholar at The Johns Hopkins Center for Health Security in Baltimore.
On March 26, county officials issued a 30-day emergency order banning unvaccinated children under 18 from being in public places such as shopping centers, businesses, restaurants, schools, and places of worship.
Insured adults and children will be covered.
According to media reports, people who have not received the MMR vaccine, or don't have evidence of immunity, and then refuse to be vaccinated could be fined $1,000. Most have been in Hasidic Jewish communities in Williamsburg and Borough Park, Brooklyn. "We've seen a large increase in the number of people vaccinated in these neighbourhoods". "I urge everyone, especially those in affected areas, to get their [mumps-measles-rubella] vaccines to protect their children, families and communities". Under the mandatory vaccination order, officials will check the vaccination records of anyone who may have been in contact with a person infected with measles, according to a statement from the DOHMH.
Officials also noted that Passover is approaching, meaning increased travel among people who could carry measles to or from NY.More news: Buss gave Magic Johnson permission to fire Walton at end of season
The outbreak has largely centred around ultra-Orthodox Jewish communities where immunisation rates are low.