The Portuguese superstar bagged an fantastic hat-trick to fire Juventus through to the last eight of the Champions League, just when they needed him most.
The Portuguese is the competition's top scorer with 124 goals in 160 games, putting him comfortably ahead of Messi, who has now netted 108 goals - albeit in just 131 appearances.
"A lot of things I liked about the Champions League", Messi told Movistar after Barca's match.More news: Tesla Should Not Have Lowered the Price of Autopilot Says Musk
Twenty minutes from time, Messi and Coutinho combined to restore the two-goal advantage, but after rounding Gorgelin, the Brazilian blasted into the side-netting.
Ronaldo has a habit of stepping up when it matters most.
Messi topped off his performance with two late assists to take him to four goal involvements on the night (which pips Cristiano Ronaldo's tally of three last night).
The little Argentine has already hit six goals this campaign at a stunning rate of one every 65 minutes in Europe.More news: Abbas aide blasts U.S. report that drops references to Israeli 'occupation'
Like it or not, comparisons will always be made between two of the greatest footballers of all-time, Cristiano Ronaldo and Lionel Messi.
Their Champions League rivalry is now poised to continue, with Juventus and Barcelona set to learn their quarter-final fate when the draw takes place on Friday at 11am.
"But the other (Ronaldo) is a beast".More news: Brazil school shooting: Deadly attack in São Paulo