Due to weaker demand, the Dubai carrier is expected to scale down these purchases and place greater focus on smaller models in a shake-up that could have implications for both Airbus and its USA rival Boeing, industry sources said.
The costly aircraft has struggled to compete with more efficient, smaller models.
The move to shut production of the A380 earlier than expected coincides with a review of purchases of very large aircraft by the plane's biggest customer, Emirates, which has a fleet of 109 "Superjumbos" and 53 left on order. - Airbus chief executive, Tom EndersWhat are the details? "Hence today's announcement is painful for us and the A380 communities worldwide".
Nevertheless, Airbus said it made £2.7bn in overall net profits - a jump of 29% on the previous year. The lessor struggled to find new customers for the aircraft so much, that it made a decision to scrap the two A380s and sell them for parts.
What does it mean for jobs?.
Airbus said it would "start discussions with its social partners in the next few weeks regarding the 3,000 to 3,500 positions potentially impacted over the next three years". Those prompted a company restructuring that cost thousands of jobs.More news: US House approves full American withdrawal from Yemen
Confirming a shake-up first reported by Reuters, it said Emirates - the largest A380 customer - had chose to reduce its orders for the iconic superjumbo and order a total of 70 of the smaller A350 and A330neo models.
Airbus makes wings for the A380 in the United Kingdom - employing 6,000 staff at Broughton and 3,000 at Filton.
Why is A380 production ending?.
But sales of the industry's largest four-engined jets have fallen due to improvements in lighter twin-engined alternatives, such as the Boeing 787 and 777 or Airbus's own A350.
In Thursday's statement Airbus said it would deliver the last 14 A380s to Emirates over the next two years, adding that the airline had ordered 70 smaller planes from the manufacturer.
Airbus will complete the remaining orders, then the factories and their workers will either be reassigned to other programs or let go.More news: Serial killer shares portraits he made of unidentified victims
When Airbus's A380 first took off it was hailed as a technological marvel that would meet airlines' needs for a new large aircraft to connect the world's crowded airport hubs - London, New York, Dubai, Tokyo.
Airbus had warned in January that it would stop making the plane if no new orders came in.
Any decision to pull the plug on the iconic European double-decker after just 12 years in service must be approved by the Airbus board, which meets on Wednesday.
Emirates long has been the largest operator of the A380.
The A380 is capable of carrying more than 800 passengers, but most airlines choose to transport no more than about 500 people, instead decking out the cabin with fancy features from in-flight bars to showers and multi-room suites that come with flourishes like butlers and sofas.
Even though Airbus was aware of the threat posed by these new types of plane, they pressed ahead.More news: The Portland Trail Blazers Signing Enes Kanter Is A Puzzling Decision
Boeing's 777X can carry 414 passengers in a two-class layout and will burn about 40 per cent less fuel per passenger than an the A380.