25 cm are in the forecast for Washington, D.C., which finds itself in the storm's sights for Sunday.
The tri-state area of Indiana-Kentucky-Ohio is under a winter storm warning, with many areas already declaring a snow emergency before the storm is expected to hit on Saturday, according to Fox 19 in Cincinnati.
The Missouri Department of Transportation warned residents not to travel in the storm if it wasn't necessary.
St. Louis could get as much as a foot of snow by late Saturday, the National Weather Service said.
The University of Missouri men's basketball game Saturday at the University of SC was moved to Sunday because of weather-related travel problems, the team tweeted. The team followed up later on saying the game was "tentatively rescheduled for Sunday". Snow is covering roads and making driving risky. It is poised to leave a blanket of snow this weekend over more than 1,500 miles from Denver to Washington.More news: Snowfall Continues to Disrupt Parts of Austria, Germany and Norway
Large sections of Missouri, Illinois and IN are under winter weather advisories, and hazardous travel conditions are expected through most of the weekend.
St. Louis recorded 10.4 inches of snow by 1:30 p.m. ET, with higher accumulations in other parts of Missouri.
The storm will gear up across central Colorado, then move east across the Plains.
He says that since the snow began falling Friday, troopers in District 11 in southwestern IL have been called to 114 crashes and a total of 261 incidents, many of which involved vehicles that had veered off roadways into ditches.
Philadelphia is expected to receive a few inches of snow, but areas north of there are expected to be spared, Orrison added.More news: Manchester United open talks with agent of Philippe Coutinho?
KOMU reported a plane slid off the runway at the Columbia Regional Airport in Missouri on Friday due to icy conditions. It would be among the city's 10 greatest snowstorms - landing at the No. 2 spot - of all time if that happens. Motorists found themselves stranded as snow-covered roads became impossible to pass. Parts of IL received over a foot. Cities such as Indianapolis can expect similar conditions as St. Louis, but as the storm moves east, the likely snowfall totals will be lower in major metro areas.
Snow is forecast for the Appalachian Mountains and the Mid-Atlantic on Saturday evening and Sunday.
Below are some other must-see images from the heart of this massive storm. Southwest Virginia could see 2 to 4 inches (5 to 10 centimeters) of snow.
Winter storm warnings have been issued from Kansas to southwestern OH as well as in parts of the Virginias, southern Maryland and North Carolina.More news: Jadon Sancho reveals Callum Hudson-Odoi talks over Bayern Munich move