Prevention will be at the heart of the NHS long-term plan, and will use new approaches like predictive prevention, which will explore how digital technology can be used to offer individuals precise and targeted health advice.
Hancock said: "Prevention saves lives and saves money".
Helen Donovan, professional lead for public health at the Royal College of Nursing, said: "Matt Hancock must realise his plans will start at a disadvantage as local authorities struggle with planned cuts to public health budgets of nearly 4% per year until 2021."Disadvantaged areas emerge worse off without these vital services, with life expectancy and the poorest bearing the brunt of underinvestment in public health".
In a keynote speech in London, he promised a greater proportion of the £20 billion a year increase for the NHS in England announced by Prime Minister Theresa May would go to primary and community care.
BMA public health committee chair, Dr Peter English, said that the plans "are a welcome step [but] the government must be realistic about what must be required in order to deliver this".More news: NASA Spots Galaxies In Form Of Smiley
The future funding for Public Health England is now an unknown quantity, and will not be revealed until the spending review next year.
"Investing in prevention is the smartest thing we can do", added Duncan Selbie, chief executive of Public Health England.
Mr Hancock warned that a 6.6% increase in emergency admissions to A&E over the previous year was "unsustainable".
But he will say the strategy is "not about penalising people".
Overall, the focus is on changing lifestyle habits like diet, exercise and sleep, taking action on mental health, and gearing up the NHS to pick up health issues and provide care sooner - for example it wants three quarters of cancers to be diagnosed at earlier stages (I or II) by 2028.More news: Pep Guardiola insists Manchester City's success is not exclusively down to money
He said now the overwhelming majority of the NHS budget was spent on acute care, with just £11 billion going to primary care, where the bulk of prevention took place.
"That isn't just the difference between life and death".
"It is the difference between spending the last 20 years of life fit and active, or in a chronic condition". So our focus must shift from treating single acute illnesses to promoting the health of the whole individual.
But she also stressed that it is "not only hospitals that are feeling the strain and we urgently need greater investment in general practice - both extra funding and additional numbers of Global Positioning System and other healthcare professionals - before we can take on the responsibility of caring for and supporting even greater numbers of patients".
"To achieve this we need to strengthen the links between employers, their unwell staff and the NHS".More news: O'Rourke optimistic while casting ballot; Cruz confident after voting early