Rashford will be hoping to prove himself to Jose Mourinho this season as he tries to hold down a regular spot in the first team under the Portuguese coach.
Phil Jones was also missing as the centre-back continues to recover from a hamstring injury while Marcos Rojo wasn't among the players spotted at the airport this morning as he's still working his way back to full fitness.
Mourinho confirmed that Shaw would start at left-back after Saturday's 2-1 win at Watford - a match Marcus Rashford missed as he started a three-match ban.More news: Joker Movie Casts Dark Knight Rises Actor As Thomas Wayne
"He (Shaw) has a chance to play, of course he has", said Mourinho.
"There are so many great young talents coming through that don't get anywhere near the amount of game time that he does". But my whole point was that it's the most hard position to come through at a top-six club.
"We are improving, we found a certain balance in the team, especially in the competitive attitude", the manager said.
Jamie Carragher has defended his recent comments on Marcus Rashford and has warned the youngster to leave Manchester United if he wants to thrive as a striker.More news: Fears 'US Border Patrol killer' may have more victims
"I don't think there's any doubt that he's already one of Man Utd's best attacking options so I would be shocked if they let him go because I don't think he needs it".
"We managed to win two hard away matches which was important for us, so I'm happy but I was happy after the Tottenham defeat. with numerous things that I saw. But it's too early".
"But I just want to remind you, in advance, that we can only start with 11 players, so when tomorrow you see the team, you could try to speak about the ones who are going to play and not about the ones who aren't".
"But the one he didn't say was that since Jose has arrived, Rashford has started at centre forward only 12 times in the Premier League".More news: Mike Zimmer has brutal quote about cutting struggling Vikings kicker
"Rashford will learn about other positions when he plays in them which is good for his development but long term I think he'll be a number nine like Thierry Henry".