The reality show's official Twitter account shared the news and said that the 19th series, which begins on Friday night, would be the last.
"Don't want to say bye to Big Brother".
Celebrity Big Brother and "civilian" Big Brother will no longer be airing on Channel 5.
"The final series of Big Brother starts tonight at 9pm", it noted.
"We'd also like to thank our brilliant presenters - Emma on "Big Brother" and Rylan from "Bit On The Side" - for their consummate professionalism, Marcus, the voice of "Big Brother" and all of the housemates who have created so many memorable moments".More news: The changing death toll from Hurricane Maria
"We are incredibly proud of Big Brother which has consistently been the highest rated show for Channel 5 over the past seven years", it said.
The UK is one of 20 countries where the show will air in 2018, including the US where Celebrity Big Brother was recently renewed, four different versions in India and last month's Celebrity Big Brother in Germany which saw a rise of 85% series on series. "We look forward to giving the final series a brilliant send-off".
In a statement, production company Endemol said they were "disappointed" not to reach an agreement with Channel 5, but "are excited about future possibilities for "Big Brother" in the UK".
The show first appeared on screens in 2000 and was extremely popular, but viewing figures have dwindled in recent years.
After Channel 4 pulled the plug Channel 5 stepped in to air the show in a two year deal in 2012.
The finale of the latest series of the celebrity version attracted 1.6 million viewers, while ratings of other programmes such as ITV2's Love Island have surged in popularity.More news: Cleveland Browns to cut ties with wide receiver Josh Gordon
Davina McCall presented the first incarnation of the show, stepping down in 2010 when it moved to Channel 5.
It was then hosted by former victor Brian Dowling before Emma Willis took over in 2013 and been narrated by Marcus Bentley for the whole 18 years the show has been on air.
The latest series of Celebrity Big Brother was won by Coronation Street star Ryan Thomas, who was at the centre of a controversy that dominated headlines when his fellow housemate, Roxanne Pallett, accused him of punching her.
"Bit On The Side" presenter Rylan Clark-Neal has also issued his own statement on Twitter, saying he will be "forever grateful" to the show, which he participated on as a celebrity contestant in 2013, prior to hosing the spin-off show.
In 2015, Channel 5 struck a deal to broadcast Big Brother for the next three years.More news: NYSC Scandal: Kemi Adeosun ‘Resigns’ As Nigeria’s Finance Minister