Three steady pars followed before Lowry finished with two birdies from the final three holes to post an error-free 64, which included six birdies and no bogeys.
Rickie Fowler was the only player who made a run at him on the sponge-like fairways of Bellerive.
Defending champion Justin Thomas made one birdie and no doubt felt like he was losing ground. I was hitting a lot of drivers.
"I feel safe where my game is", Woodland said. "But at the same time, it can show its teeth if you're not driving it well".More news: Chelsea Send Batshuayi, Zouma Out On Loan
"That stemmed the momentum a little bit", Woods said. His other birdie came at the par-5 17th, where he hit the green in two and two-putted from 30 feet. It was his fourth round of 66 or better this year, including his third round at the British Open.
"I just have to make birdies", Woods said of his mindset going into the third round. "Get in the fairway, the greens are still soft enough that you can still attack". If you do that well, and, obviously, in there you're going to make those putts. Brooks Koepka and Charl Schwartzel had the best rounds of the field, firing 7-under-par 63s to tie the tournament record for the lowest score in a round. It was 141 at Atlanta Athletic Club in 2001.
The PGA have confirmed their third-round tee times, with Woods out on the course at 12:21pm local time.
"I have my brother on the bag, and he's doing a great job, really enjoyed it", said Lowry, who had restarted on four-under.
Phil Mickelson played nine holes, and he won't be playing any more.
Woodland had a 4-under 66 and set the PGA Championship record with a 36-hole score of 130.More news: Pogba penalty sets United on way to win over Leicester
Paul Dunne, meanwhile, will also miss the cut as the Greystones native is five over with one to play.
"I feel like we're in a good spot", Fowler said.
Woodland took a one-stroke lead into the day after shooting a 64 Thursday and chipped his way to a birdie on his second hole Friday, No. 11. No. 9 Bryson DeChambeau and No. 11 Matt Kuchar also missed the cut.
Playing with - and likely auditioning for Ryder Cup captain Jim Furyk - Finau began with five straight birdies before posting a triple bogey on No. 6.
Kisner cooled on the second nine and Woodland registered another solid side with birdies on 2 and 3 and a bogey on 4.More news: Trump doubles tariffs on Turkey, stoking jitters