The remarkable match between two of the men's game's legendary players began on Friday evening after the outcome of Anderson's win over Isner and had to be halted after 11pm after Djokovic had taken the third set on a breathtaking tie-break.
"Yes, there were moments of doubt, of frustration, disappointment, where you're questioning whether you want to keep it going", said Djokovic, back in a Slam final for the first time since finishing runner-up at the 2016 US Open.
Isner had held serve 110 straight times since the start of the tournament before Anderson, a former NCAA tennis rival, broke him four times.
Novak Djokovic was understandably emotional as he gave a post-match interview immediately after booking his place in Sunday's final.
Fans, including the Duchess of Cambridge and Duchess of Sussex in the front row of the Royal Box, were treated to breathtaking deciding set as Djokovic finally prevailed after five hours and 15 minutes.More news: Meghan Markle Will Support Friend Serena Williams This Weekend At Wimbledon
That's 99 games, 102 combined aces and 569 points.
In the second longest match in Wimbledon history, Anderson triumphed after 6 hours and 36 minutes, 7-6 (6) 6-7 (5) 6-7 (9) 6-4 26-24.
Wimbledon bosses closed the roof before the start but a 23:00 curfew meant the match will resume at 13:00 on Saturday. "They've been watching us for over six hours".
Instead, the two players - and a disappointed audience - were sent home after the third set with Djokovic leading 6-4, 3-6, 7-6 (9) following a tense tiebreaker that had more entertaining rallies than some entire matches. "I don't see the other opposing view of not incorporating a fifth-set tiebreaker at all the Slams". They're better off than ever, and therefor free to do the sensible thing. Isner did not have his serve broken once in the tournament entering the match.More news: Build-A-Bear "Pay Your Age Promotion" prompts chaos across the nation
"I think it's long overdue".
As the fifth set dragged on and on, the American Isner appeared more visibly exhausted and had to survive more scares on his own serve than Anderson.
The ridiculous length of the Anderson-Isner clash left Nadal and Djokovic waiting until 8pm local time before stepping on court for their box office semi- final.
Isner said that being part of yet another record-breaking match did not help ease his pain.More news: Mueller team pressing Roger Stone associates in Russian collusion probe
"It's up to me to not let this match linger, going forward, when I get back in America playing on the hard courts, which is my favorite surface", Isner said as he shifts focus to the U.S. Open starting in late August.