In recent years Sky's riders have been punched and spat at, while Froome allegedly had a cup of urine thrown at him in 2015 by a spectator who shouted "Doper!" as he passed.
The four-time Tour de France victor tested positive for excessive levels of salbutamol during last year's Vuelta a Espana but the World Anti-Doping Agency concluded Froome's results did not constitute an adverse analytical finding.
Froome admitted the investigation has "undoubtedly been damaging" but said he is glad to "draw a line in the sand and move on".
"I just raced the Giro in May with the Salbutamol thing hanging over me, and nothing happened there", Froome added.More news: The world's oldest colour? Bright pink, researchers say
"But really I can't make a prediction about how it's going to go".
"The people that made the decision were the UCI and WADA (the World Anti-Doping Agency), not Team Sky, and I think that's where the information about how that decision was made should come from, not necessarily ourselves", he said. "I have heard calls, sometimes completely irrational, to violence on the Tour de France", Lappartient said.
Earlier this week UCI president David Lappartient appealed to cycling fans for the safety of Froome in an interview posted on social media.More news: As water level surged, Thai cave rescue almost ended in disaster
"I cannot accept that and I call on all spectators to protect all the athletes and to respect the judicial decision so that Chris Froome can compete in a safe and serene environment like all other athletes".
On the eve of the start of the Tour, the British rider who was jeered when he was presented to French cycling fans on Thursday, said he was relieved that cycling authorities this week ended a probe into doping suspicions surrounding the four-times victor.
First French sprinter Arnaud Demare saw his hopes of a stage win ended in a tumble, then Team Sky's Egan Bernal, the youngest rider in the race at 21, slid off the side of the road in another incident.
"I've always been impressed by the way he is off the bike", Thomas said. "That's just something you deal with in the moment".More news: LeBron James Sells Movie Script, Might Star In It
To win the Giro [d'Italia] and come here for the double is exceptional.