Assad focused on the remaining besieged rebel pockets last month after taking back Eastern Ghouta, the biggest insurgent enclave near Damascus, in a ferocious, weeks-long offensive.
The militants and their relatives were evacuated from areas straddling the boundary between the provinces of Homs and Hama to Idlib province under a deal reached between the militant groups and the Syrian government.
The government has yet to formally announce the recapture of the enclave, but a Syrian military officer told Syrian TV the government is now in control of the last rebel enclave in Homs after "overpowering terrorism".
Hundreds of people gathered in the centre of the town of Talbiseh in Homs province to welcome the return of government security forces and attend a flag-raising ceremony on the main square.More news: Multiple people hurt after school bus, dump truck crash on NJ highway
The Syrian government forces have regained full control over central Syria after the Takfiri militants agreed to leave the militant-held final pockets in the region as part of an evacuation deal with Damascus.
The opposition has called it a policy of forced displacement amounting to demographic change to force out Assad's opponents.
Following Tuesday's advance, the adjoining Yarmouk Palestinian camp and the nearby al-Tadamon neighborhood are the only areas south of Damascus still under militant control.
A small pocket in southern Homs province, near the border with Iraq, is controlled by US -backed rebels.More news: Report that Obama FBI spied on campaign could be 'bigger than Watergate'
A total of 34,500 people - armed men and their families - were transferred out of the area as part of the deal, according to the Britain-based observatory.
Russian Federation launched an air campaign on behalf of President Bashar Assad in 2015, helping to turn the tide of the war in his favor.
Meanwhile, two people have been killed and 19 others injured due to a shell fired in Damascus.
The last besieged rebel area, being fully evacuated on Wednesday, is the large enclave located between the cities of Hama and Homs around the towns of Rastan, Talbiseh and Houleh.More news: Could North Carolina be site of new Apple campus?
In this photo released Tuesday, May 15, 2018 by the Syrian official news agency, SANA, workers clean a road and fix the streetlights, after the Syrian government secured roads linking south, central and northern Syria.