Djokovic has also had to contend with injury in recent months and is not being tipped to mount a serious challenge for Nadal's Monte Carlo Crown.
He opens with a bye and then either Pablo Cuevas or Fernando Verdasco - both are inconsistent these days - before a potential round three with Milos Raonic, another player whose level is tough to judge on clay now. As you may expect from this, big-servers are not suited at all in what are very different conditions to what was witnessed last week on the quicker clay in Houston, and in Monte Carlo in this time period, a mere 0.30 aces per game were served, down from the 0.38 ATP clay average.More news: Inflation dips to 2.47 per cent in March
But with 20-time major victor Federer again skipping the clay season, Nadal must wait a while longer to try and avenge a run of five straight defeats to the Swiss star.
He feels at home at the picture-postcard tournament with its center court perched over the glittering Mediterranean sea.
Joining defending champion Nadal as part of the superstar line-up in Monte Carlo is Novak Djokovic, Marin Cilic and the talented Grigor Dimitrov.
The 30-year-old dropped just eight points during the first set as he dominated against his compatriot, and it was a similar story in the second.More news: Ready for talk to bring peace back to Syria: Macron
It was the 12-time Grand Slam champion's first win at a regular ATP Tour event this season, after losing his opening matches in Indian Wells and Miami to Taro Daniel and Benoit Paire respectively. "He's always there for me, knows me inside out".
Berdych, a Monaco resident, was runner-up to Djokovic in Monte Carlo in 2015.
The former-top ranked Djokovic has been troubled by a persistent right elbow injury and his ranking has tumbled to No. 13.
He may have to defeat the likes of Rublev and Djokovic before a potential quarter-final showdown with Nadal.More news: Thousands of protesters take to the streets in Armenian capital
"I've had a very hard time in the last 12 months with the injury and everything else that's happened". He even beat Nadal during a glorious run of seven straight finals and holds a 26-24 winning record against him.