Tonight's opposition Sevilla have had mixed form since they met United at home and have fallen away from the top four.
With Pogba missing, Mourinho could well go for the same starting line-up as we saw against Liverpool. There were, however, wins against both Malaga and Athletic Bilbao in between that sandiwch of defeats.
"Sevilla and Brighton are more important games than Liverpool", said Mourinho, via the Mirror.
"So imagine if we were knocked out - it would be considered a disaster, but for me it would be a disappointment".More news: Citigroup Cuts American Tower (AMT) Price Target to $162.00
Antonio Valencia has been effective in most games this season and should keep his place as a right-back while Luke Shaw could replace Ashley Young, who put in a superb shift at the weekend.
Marcus Rashford rose to the occasion in his first Premier League start since Boxing Day, scoring twice against Liverpool.
Chris Smalling grabbed one back before a composed Romelu Lukaku finish drew United level.
The 36-year-old club captain has featured sparingly for United this season, having been sidelined earlier in the campaign due to a heart scare. Think a 2-1 defeat to Huddersfield Town, a draw away at Leicester City.
It's been one of the best spells in Manchester United's season in recent weeks.More news: Calm before the storm? North Korea still mum on Trump summit
The France global midfielder was a late withdrawal from the Red Devils folds to face Liverpool in Premier League competition on Saturday.
Matic hopes to make the United fans proud again on Tuesday after a ruthless first-half display at Old Trafford, where things would have been far less nervy had Juan Mata managed to make it 3-0 with an acrobatic attempt.
He returned to action last month but, speaking at a news conference ahead of Tuesday's Champions League last-16 match against Sevilla, Carrick confirmed the current campaign will be his last. That means United must win. It is Sevilla. I know it is very hard to go through.
"I said when he first signed, he is a Man United player, he suits the way we play, he has got that excitement, he always looks forward, he is dynamic and in the end you can judge him in the first few games or whatever but I think over time he will be terrific and I have no doubts about it".More news: Must act quickly on European investment budget - Merkel