CLubs like Barcelona, Real Madrid, Bayern Munich and United's local rivals and runaway Premier League leaders Manchester City, are favourites to win the competition.
That's compared with five losses in the 21 starts he's made across all competitions, pointing to an inferior loss ratio of one defeat every 4.3 games.
"But when a team gets in the last eight, you start smelling semi-finals and I think when a team gets into the last eight, the feeling is, of course, you are among the best".
Writing in his column for Sky Sports, Nicholas said: "This might not be as big for the fans, but this is as big as Saturday in terms of it being huge for them to be in Champions League quarter-finals".More news: In Ireland, there were mass protests against abortion
United boss Mourinho is wary of the threat Sevilla pose, however, having witnessed the Spaniards - fifth in La Liga - hold Liverpool to 2-2 and 3-3 draws in the group stage of this season's competition. "We are playing against a team that didn't lose against Liverpool home and away", he told reporters at his pre-match press conference.
"Liverpool are a very good team, with an important stadium and with a big tradition, so it says Sevilla are a really good team".
Europa League success last season rescued Mourinho's first year in charge at Old Trafford, securing a place in Europe's premier club competition as a result.
Dutch referee Danny Makkelie will get the match at Old Trafford under way at 7.45pm (GMT).More news: Sevilla boss Vincenzo Montella reveals Champions League tactics
Mourinho has begun the process of reversing that decline, even though United snuck into the Champions League through the back door, by winning the Europa League last season.
Speaking to La Sexta, and covered by Marca and others, Mourinho was asked about De Gea potentially moving to Real Madrid in the summer transfer window.
"I see him here", said Mourinho. "But he trained a little bit".More news: What Do Analysts Say About Vipshop Holdings Limited (VIPS)