The bus, carrying students on a school trip from Houston, plunged down the ravine, with authorities rushing to the scene.
An Alabama state trooper says the driver was killed when a tour bus carrying Texas high school students home from a Disney World trip plunged into a ravine.
The passengers are reportedly mostly band members from Channel View High School in Texas.
"We have multiple injuries; the bus went down into a ravine", said Chris Elliott, a Baldwin County commissioner who helped out at the county emergency management center following the crash.More news: Foreign Law Firms Not Allowed To Practice In India
Mack told AL.com that there was once critical injury and five serious injuries.
The sheriff said it wasn't immediately clear what caused the bus to enter the grassy median, which abruptly ends at a steep embankment where the interstate passes over Cowpen Creek, about 25 miles west of Pensacola, Fla., and 30 miles east of Mobile, Ala.
Jesus Tejada captured the aftermath of the accident in a Facebook video which shows the bus wreckage on it's side in the ravine. Baldwin County Sheriff Huey Hoss Mack confirmed the death Tuesday morning while talking to news reporters.
Sacred Heart Hospital in Pensacola confirmed on its website that it had received 18 patients from the bus wreck on Tuesday.More news: University staff reject union deal on pensions
A second bus carrying students from the Disney trip is continuing on to Houston. The interstate was closed in each direction as passengers were taken to hospitals.
Mack said it was expected I-10 would remain shut down at least until noon.
KPRC in Houston reports that First Class Tours owns the bus, and safety records indicate the company has had four crashes in the last two years. "We pledge our assistance in cooperating with local authorities in the investigation", they said in a statement to KHOU.
Lowery said uninjured passengers will be reunited with family members and Channelview school officials at Coastal Church on County Road 64 in Daphne, Alabama.More news: Ryan Giggs makes Manchester United claim ahead of Sevilla Champions League clash