The interior ministry on Saturday said 2,219 people were murdered in December 2017.
It is also nearly 2,000 more than the previous high recorded in 2011 when the war on drugs initiated by former president Felipe Calderón reached its peak.
Brazil and Colombia were also more violent than Mexico in 2017, with both South American countries recording rates of around 27 homicides per 100,000 inhabitants, Associated Press reported. El Salvador reported a rate of 60.8 for 2017.
The murder rate for Mexico as whole was 20.5 per 100,000 residents, more than four times higher than the USA rate.More news: Lara Croft embarks on an adventure in new Tomb Raider TV spot
It was the highest total of murders in a single year since 1997, reports the Wall Street Journal, citing data released Sunday by Mexico's interior ministry. That year, authorities recorded 22,409 homicides. He placed the homicide rate closer to 24 per 100,000 inhabitants.
Despite President Donald Trump's tweet last week claiming Mexico is "now rated the number one most unsafe country in the world", there are several nations in Latin America with higher rates.
But some parts of Mexico were singularly violent: The Pacific coast state of Colima had a rate of 93.6 murders per 100,000 inhabitants. Guerrero, home to the resort town of Acapulco, had a rate of 64.2.
At the outset of Mexican President Enrique Pena Nieto's term, Mexico had appeared to turn the corner on the horrific violence it experienced during the tenure of former President Felipe Calderon from 2006 to 2012.More news: Intel now knows why Spectre and Metldown patches are causing reboots
However, while homicide rates dropped between 2012 and 2014, in 2015 they began to rise again.
Earlier in the new year, five severed heads were found arranged on the hood of a taxi in the tourist town of Tlacotalpan, Veracruz and four others found in another city in the same state. Thus, it is the state with more murders, followed by the state of Mexico, Baja California, Chihuahua, Veracruz and Jalisco. In the beginning of January, nine people were brutally killed in the Gulf coast state of Veracruz in a suspected conflict between rival gang factions, Reuters reported.
Mexico has struggled with years of violence as the government has battled vicious drug cartels that have increasingly splintered into smaller, more bloodthirsty, gangs. "There are social triggers, institutional ones, historical ones, issues of land rights, it is complex", he explained. "Drug trafficking is one of them, of course, but it is not the only one", Hope told AP, while suggesting that the increasing toll is a "regression to the mean" over the lower murder rates Mexico enjoyed between 1997 and 2007.
Last year, however, saw renewed inter-cartel fighting that sent homicides soaring 63 percent from 2014.More news: DMV accepting applications for optional "REAL ID" cards